Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Med Chem. 2008 Jul 10;51(13):3681-3. doi: 10.1021/jm800521j. Epub 2008 Jun 18.

Hydrochalarones: a novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast.

Author information

  • 1Luna nanoWorks (A Division of Luna Innovations, Incorporated), 521 Bridge Street, Danville, Virginia 24541, USA. macfarlandd@lunainnovations.com


Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Write to the Help Desk