Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2008 Jun 13;320(5882):1492-6. doi: 10.1126/science.1158042.

Regulation of hepatic lipogenesis by the transcription factor XBP1.

Author information

  • 1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. ahlee@hsph.harvard.edu

Abstract

Dietary carbohydrates regulate hepatic lipogenesis by controlling the expression of critical enzymes in glycolytic and lipogenic pathways. We found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid synthesis in the liver. XBP1 protein expression in mice was elevated after feeding carbohydrates and corresponded with the induction of critical genes involved in fatty acid synthesis. Inducible, selective deletion of XBP1 in the liver resulted in marked hypocholesterolemia and hypotriglyceridemia, secondary to a decreased production of lipids from the liver. This phenotype was not accompanied by hepatic steatosis or compromise in protein secretory function. The identification of XBP1 as a regulator of lipogenesis has important implications for human dyslipidemias.

Comment in

PMID:
18556558
[PubMed - indexed for MEDLINE]
PMCID:
PMC3620093
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk