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Gene Expr Patterns. 2008 Jul;8(6):389-96. doi: 10.1016/j.gep.2008.05.001. Epub 2008 May 10.

Expression of EGFL7 in primordial germ cells and in adult ovaries and testes.

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  • 1Department of Public Health and Cell Biology, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.


We have previously reported the isolation and characterization of a novel endothelial-restricted gene, Egfl7, that encodes a secreted protein of about 30-kDa. We and others demonstrated that Egfl7 is highly expressed by endothelial cells during embryonic development and becomes down-regulated in the adult vasculature. In the present paper, we show that during mouse embryonic development, Egfl7 is also expressed by primordial germ cells (PGC). Expression is down-regulated when PGCs differentiate into pro-spermatogonia and oogonia, and by 15.5 dpc Egfl7 can no longer be detected in the germ line of both sexes. Notably, Egfl7 is again transiently up-regulated in germ cells of the adult testis. In contrast, expression in the ovary remains limited to the vascular endothelium. Our results provide the first evidence of a non-endothelial expression of EGFL7 and suggest distinctive roles for Egfl7 in vascular development and germ cell differentiation.

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