Vaccine. 2008 Jul 23;26(31):3842-52. Epub 2008 Jun 2.

A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats.

McEachern JA, Bingham J, Crameri G, Green DJ, Hancock TJ, Middleton D, Feng YR, Broder CC, Wang LF, Bossart KN.

Source

CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, Victoria 3220, Australia.

Abstract

Nipah virus (NiV) and Hendra virus (HeV) are closely related deadly zoonotic paramyxoviruses that have emerged and re-emerged over the last 10 years. In this study, a subunit vaccine formulation containing only recombinant, soluble, attachment glycoprotein from HeV (sG(HeV)) and CpG adjuvant was evaluated as a potential NiV vaccine in the cat model. Different amounts of sG(HeV) were employed and sG-induced immunity was examined. Vaccinated animals demonstrated varying levels of NiV-specific Ig systemically and importantly, all vaccinated cats possessed antigen-specific IgA on the mucosa. Upon oronasal challenge with NiV (50,000TCID50), all vaccinated animals were protected from disease although virus was detected on day 21 post-challenge in one animal. The ability to elicit protective systemic and mucosal immunity in this animal model provides significant progress towards the development of a human subunit vaccine against henipaviruses.

PMID:: 18556094; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

AI057168/AI/NIAID NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge. [Vaccine. 2011]
A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge.
Pallister J, Middleton D, Wang LF, Klein R, Haining J, Robinson R, Yamada M, White J, Payne J, Feng YR, et al. Vaccine. 2011 Aug 5; 29(34):5623-30. Epub 2011 Jul 1.
Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine. [J Virol. 2006]
Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine.
Mungall BA, Middleton D, Crameri G, Bingham J, Halpin K, Russell G, Green D, McEachern J, Pritchard LI, Eaton BT, et al. J Virol. 2006 Dec; 80(24):12293-302. Epub 2006 Sep 27.
Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble G glycoprotein of Hendra virus. [J Virol. 2005]
Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble G glycoprotein of Hendra virus.
Bossart KN, Crameri G, Dimitrov AS, Mungall BA, Feng YR, Patch JR, Choudhary A, Wang LF, Eaton BT, Broder CC. J Virol. 2005 Jun; 79(11):6690-702.
Review Developments towards effective treatments for Nipah and Hendra virus infection. [Expert Rev Anti Infect Ther. 2...]
Review Developments towards effective treatments for Nipah and Hendra virus infection.
Bossart KN, Broder CC. Expert Rev Anti Infect Ther. 2006 Feb; 4(1):43-55.
Review Henipavirus: a review of laboratory animal pathology. [Vet Pathol. 2010]
Review Henipavirus: a review of laboratory animal pathology.
Williamson MM, Torres-Velez FJ. Vet Pathol. 2010 Sep; 47(5):871-80. Epub 2010 Aug 3.

See reviews... See all...

Cited by 8 PubMed Central articles

A neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge. [Sci Transl Med. 2011]
A neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge.
Bossart KN, Geisbert TW, Feldmann H, Zhu Z, Feldmann F, Geisbert JB, Yan L, Feng YR, Brining D, Scott D, et al. Sci Transl Med. 2011 Oct 19; 3(105):105ra103.
Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection. [J Virol. 2011]
Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection.
Rockx B, Brining D, Kramer J, Callison J, Ebihara H, Mansfield K, Feldmann H. J Virol. 2011 Aug; 85(15):7658-71. Epub 2011 May 18.
Vaccine potential of Nipah virus-like particles. [PLoS One. 2011]
Vaccine potential of Nipah virus-like particles.
Walpita P, Barr J, Sherman M, Basler CF, Wang L. PLoS One. 2011 Apr 6; 6(4):e18437. Epub 2011 Apr 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A recombinant subunit vaccine formulation protects against lethal Nipah virus ch...
A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats.
Vaccine. 2008 Jul 23 ;26(31):3842-52. Epub 2008 Jun 2 .

PubMed
Non-small cell lung cancer and silent brain metastasis. Survival and prognostic ...
Non-small cell lung cancer and silent brain metastasis. Survival and prognostic factors.
Lung Cancer. 2009 Jan ;63(1):140-5. Epub 2008 Jun 16 .

PubMed
Clarifying CB2 receptor-dependent and independent effects of THC on human lung e...
Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells.
Toxicol Appl Pharmacol. 2008 Sep 15 ;231(3):282-90. Epub 2008 May 9 .

PubMed
Medical spa marketing.
Medical spa marketing.
Dermatol Clin. 2008 Jul ;26(3):391-401, vi.

PubMed
Procedures offered in the medical spa environment.
Procedures offered in the medical spa environment.
Dermatol Clin. 2008 Jul ;26(3):341-58, v.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: