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Cell. 2008 Jun 13;133(6):947-8. doi: 10.1016/j.cell.2008.05.035.

Rewiring bacteria, two components at a time.

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  • 1Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, 44 Cummington St., Boston, MA 02215, USA.


In this issue, Skerker et al. (2008) present a rational method for rewiring the protein-protein interactions and output responses of prokaryotic two-component signal transduction systems. This work has important implications for understanding the specificity of protein interactions and for designing protein-based synthetic signaling cascades.

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