Whole-brain statistical parametric maps with consistent p scale shown. Note that regardless of experiment (pitch or duration) and regardless of tone set heard (all tones or deviants only), there is no area of the brain in which control subjects activated more than SPD subjects. a. Pitch experiment, all tones (standard+deviant) heard analyzed together. b. Pitch experiment deviant condition. Note significantly more activation in SPD subjects compared with control subjects in the region of the STG bilaterally. Thresholded at the p<0.001 level with an extent of activation cluster size limit set at 240 voxels. MNI coordinates and cluster significance by two-tailed t tests were: (−52, −22, −2, T=5.3, p<0.001), (54, −46, −2, T=5.3, p<0.001), (54, −46, 18, T=4.85, p<0.001). c. Duration experiment, all tones (standard+deviant) condition. Thresholded at the p<0.01 level with an extent of activation cluster size limit set at 0 voxels to ensure all visible super-threshold activation. MNI coordinates and cluster significance by two-tailed t tests were: (2, 22, 10, T=5.67, p<0.0005) and (−14, 4, 24, T=5.3, p<0.0005). d. Duration experiment, deviant condition. SPD subjects activated more to deviant tones than comparison subjects in left temporal and bilateral parietal regions. Thresholded at the p<0.01 level with an extent of activation cluster size limit set at 240 voxels for temporal lobe regions, 0 voxels for parietal regions in order not to lose relevant findings in that area. MNI coordinates and cluster significance by two-tailed t tests were: for temporal lobe regions, (−48, −28, −4, T=2.83, p=0.005 and −22, −88, 2, T=3.1, p=0.003); for parietal lobe regions, (−26, −42, 38, T=4.0, p<0.001), (−24, −20, 42, T=3.2, p=0.002), (28, −40, 38, T=3.36, p=0.001). Note standardized color bars across images reflect relative T scores. Neurological convention (left is left).