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1: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Aug;106(2):e46-51. Epub 2008 Jun 13.Click here to read Links

Tooth abnormalities and soft tissue changes in patients with velocardiofacial syndrome.

da Silva Dalben G, Richieri-Costa A, de Assis Taveira LA.

Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, Brazil. gsdalben@usp.br

OBJECTIVE: The objective of this study was to investigate the prevalence of tooth abnormalities and soft tissue changes in patients with velocardiofacial syndrome. STUDY DESIGN: Twenty-six patients with velocardiofacial syndrome were examined to investigate the presence of tooth abnormalities and soft tissue alterations. The occurrence of tooth agenesis and supernumerary teeth was compared to patients without morphofunctional alterations, matched for gender and age. RESULTS: Of all patients, 76.92% exhibited at least one tooth abnormality, with predominance of hypoplastic alterations, especially represented by hypodevelopment of the lingual cusp of mandibular first premolars and enamel opacities. The occurrence of tooth agenesis and supernumerary teeth was similar in both study and control groups. CONCLUSION: the present results suggest an association between hypodevelopment of the lingual cusp of mandibular first premolars and enamel opacities, yet these findings still require corroboration. Future studies should further investigate these aspects in larger samples compared to control groups, as well as employing molecular genetics techniques.

PMID: 18554940 [PubMed - indexed for MEDLINE]