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    Tissue Antigens. 2008 Aug;72(2):162-5. Epub 2008 Jun 28.

    Vascular endothelial growth factor gene polymorphisms in Turkish patients with sarcoidosis.

    Seyhan EC, Cetinkaya E, Altin S, Gunluoglu MZ, Demir A, Koksal V, Issever H.

    Source

    Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey. drekremcs@yahoo.com

    Abstract

    Polymorphism at +813 locus of vascular endothelial growth factor (VEGF) gene is considered to decrease predisposition to sarcoidosis. Our study aimed to investigate the roles of this polymorphism in the development and extent of sarcoidosis. We examined polymorphisms of the VEGF gene in 90 cases with histopathological diagnosis of sarcoidosis and in 110 healthy subjects. VEGF +813 gene polymorphisms were determined using a polymerase chain reaction-based method after DNA isolation. A significant increase in the frequency of the T allele was found in healthy subjects (odds ratio 0.55; 95% confidence interval 0.32-0.97, P<0.05). Our results suggest that increase in rarer T allele at + 813 locus of VEGF gene may diminish susceptibility to sarcoidosis in Turkish population.

    PMID:
    18554246
    [PubMed - indexed for MEDLINE]

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