Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H447-53. Epub 2008 Jun 13.

The physiological basis of intracrine stem cell regulation.

Source

Ochsner Clinic Foundation, New Orleans, LA 70121, USA. rre@ochsner.org

Abstract

Intracrine peptides and proteins participate in the regulation of adult and pleuripotential embryonic-like stem cells. Included among these factors are VEGF, dynorphin, the readthrough form of acetylcholinesterase, Oct3/4, Pdx-1, Pax-6, and high-mobility group protein B1, among others. In some cases, the establishment of intracrine feedback loops can be shown to be relevant to this regulation, consistent with previously proposed principles of intracrine action. Here the role of intracrines in stem cell regulation is reviewed, with particular attention to the intracrine regulation of cardiac stem cells. The reprogramming of cells to restore the pleuripotent phenotype and the possible role of stem/progenitor cells in neoplasia are also discussed.

PMID:: 18552159; [PubMed - indexed for MEDLINE]
PMCID:: PMC2519209

Free PMC Article

Images from this publication.See all images (2) Free text

Publication Types, MeSH Terms, Substances, Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Stem Cells - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells. [Circ Res. 2003]
Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells.
Ventura C, Zinellu E, Maninchedda E, Maioli M. Circ Res. 2003 Apr 4; 92(6):623-9. Epub 2003 Mar 6.
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. [Nature. 2008]
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors.
Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Araúzo-Bravo MJ, Ruau D, Han DW, Zenke M, et al. Nature. 2008 Jul 31; 454(7204):646-50. Epub 2008 Jun 29.
Review Autocrine and intracrine signaling for cardiogenesis in embryonic stem cells: a clue for the development of novel differentiating agents. [Handb Exp Pharmacol. 2006]
Review Autocrine and intracrine signaling for cardiogenesis in embryonic stem cells: a clue for the development of novel differentiating agents.
Ventura C, Branzi A. Handb Exp Pharmacol. 2006; (174):123-46.
Expression of pluripotent stem cell reprogramming factors by prostate tumor initiating cells. [J Urol. 2010]
Expression of pluripotent stem cell reprogramming factors by prostate tumor initiating cells.
Bae KM, Su Z, Frye C, McClellan S, Allan RW, Andrejewski JT, Kelley V, Jorgensen M, Steindler DA, Vieweg J, et al. J Urol. 2010 May; 183(5):2045-53. Epub 2010 Mar 19.
Review The basis of an intracrine pharmacology. [J Clin Pharmacol. 2008]
Review The basis of an intracrine pharmacology.
Re RN, Cook JL. J Clin Pharmacol. 2008 Mar; 48(3):344-50. Epub 2008 Jan 25.

See reviews... See all...

Cited by 2 PubMed Central articles

A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling. [Stem Cell Rev. 2010]
A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling.
Lorz C, García-Escudero R, Segrelles C, Garín MI, Ariza JM, Santos M, Ruiz S, Lara MF, Martínez-Cruz AB, Costa C, et al. Stem Cell Rev. 2010 Jun; 6(2):162-77.
Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action. [Am J Physiol Heart Circ Physio...]
Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action.
Re RN, Cook JL. Am J Physiol Heart Circ Physiol. 2009 Sep; 297(3):H893-901. Epub 2009 Jul 10.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The physiological basis of intracrine stem cell regulation.
The physiological basis of intracrine stem cell regulation.
Am J Physiol Heart Circ Physiol. 2008 Aug ;295(2):H447-53. Epub 2008 Jun 13 .

PubMed
Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide ide...
Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.
Cancer Res. 1991 Aug 1 ;51(15):3996-4000.

PubMed
Monitoring the efficacy of adoptively transferred prostate cancer-targeted human...
Monitoring the efficacy of adoptively transferred prostate cancer-targeted human T lymphocytes with PET and bioluminescence imaging.
J Nucl Med. 2008 Jul ;49(7):1162-70. Epub 2008 Jun 13 .

PubMed
[Evaluation of hyperbaric oxygen and pharmacological therapy in sudden hearing l...
[Evaluation of hyperbaric oxygen and pharmacological therapy in sudden hearing loss].
Otolaryngol Pol. 2007 ;61(5):887-91.

PubMed
[Complications of otitis media in children in the era of antibioticotherapy].
[Complications of otitis media in children in the era of antibioticotherapy].
Otolaryngol Pol. 2007 ;61(5):779-83.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The physiological basis of intracrine stem cell regulation.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information