Format

Send to

Choose Destination
See comment in PubMed Commons below
Reprod Toxicol. 2008 Aug;25(4):408-12. doi: 10.1016/j.reprotox.2008.04.010. Epub 2008 May 3.

Folate fortification and supplementation--are we there yet?

Author information

  • 1Department of Neonatology, Hadassah and Hebrew University Medical Centre, Jerusalem, Israel.

Abstract

BACKGROUND:

Folic acid fortification of flour has significantly decreased the incidence of neural tube defects (NTDs). We aimed at examining whether Ontario women of child-bearing age exhibit protective levels of RBC folate.

METHODS:

We reviewed laboratory databases on RBC folic acid from pre and post fortification years. The data included age, gender, RBC folate, hemoglobin, mean cell volume and pregnancy test. We examined a sub-set of females at ages 14-45 years who were non-anemic and normocytic. Complete protection against NTD was defined as RBC folate concentration above 900 nmol/L.

RESULTS:

In 2006, 40% of the women of child-bearing age and 36% of pregnant women, exhibited RBC folate levels below 900 nmol/L, rendering them sub-optimally protected against NTD.

CONCLUSION:

A considerable proportion of pregnant women is still at risk of having a baby with NTD. This should be remedied by increasing the mandatory concentrations of folic acid required in flour, complemented by public education and increasing the folic acid in prenatal supplements.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk