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Immunity. 2008 Jun;28(6):729-31. doi: 10.1016/j.immuni.2008.05.006.

Bridging Toll-like- and B cell-receptor signaling: meet me at the autophagosome.

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  • 1Genentech, Inc., 1 DNA Way, MS 93b, South San Francisco, CA 94080, USA. monroe.john@gene.com


In this issue of Immunity, Chaturvedi et al. (2008) describe a mechanism for the bridging of innate and adaptive immune receptor functions. In their model, B cell-receptor signaling induces the fusion of Toll-like receptor 9 (TLR9)-containing endosomes with internalized signaling-competent BCR into autophagosomes.

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