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Anaesthesia. 2008 Sep;63(9):941-7. doi: 10.1111/j.1365-2044.2008.05523.x. Epub 2008 Jun 10.

Delirium is associated with early postoperative cognitive dysfunction.

Author information

  • 1VA Boston Healthcare System, Geriatric Education and Clinical Center; Brigham and Women's Hospital, Division of Aging, Harvard Medical School, Boston, MA, USA. jrudolph@partners.org

Abstract

The purpose of this analysis was to determine if postoperative delirium was associated with early postoperative cognitive dysfunction (at 7 days) and long-term postoperative cognitive dysfunction (at 3 months). The International Study of Postoperative Cognitive Dysfunction recruited 1218 subjects >or= 60 years old undergoing elective, non-cardiac surgery. Postoperatively, subjects were evaluated for delirium using the criteria of the Diagnostic and Statistical Manual. Subjects underwent neuropsychological testing pre-operatively and postoperatively at 7 days (n = 1018) and 3 months (n = 946). Postoperative cognitive dysfunction was defined as a composite Z-score > 2 across tests or at least two individual test Z-scores > 2. Subjects with delirium were significantly less likely to participate in postoperative testing. Delirium was associated with an increased incidence of early postoperative cognitive dysfunction (adjusted risk ratio 1.6, 95% CI 1.1-2.1), but not long-term postoperative cognitive dysfunction (adjusted risk ratio 1.3, 95% CI 0.6-2.4). Delirium was associated with early postoperative cognitive dysfunction, but the relationship of delirium to long-term postoperative cognitive dysfunction remains unclear.

PMID:
18547292
[PubMed - indexed for MEDLINE]
PMCID:
PMC2562627
Free PMC Article

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