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Opt Express. 2008 May 26;16(11):8117-25.

Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from polarization-sensitive optical coherence tomography.

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  • 1Institute of Electro-optical Science and Technology, National Taiwan Normal University, 88, Sec. 4, Ting-Chou Road, Taipei 116, Taiwan.


In this research, we assessed arterial characteristics in human atherosclerosis by determining both scattering and birefringence properties of vessel tissue from polarization-sensitive optical coherence tomography (PS-OCT) images. We demonstrated that optical characteristics including scattering coefficient (mu(s)), effective anisotropy factor (g(eff)), birefringence coefficient (Delta n), and fast-axis angle (beta) of normal and different kinds of atherosclerotic lesions in human vessels can be quantitatively described. Based on our findings, a quantitative PS-OCT image criterion for plaque characterization was constructed.

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