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Nat Rev Mol Cell Biol. 2008 Aug;9(8):655-62. doi: 10.1038/nrm2430. Epub 2008 Jun 11.

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization.

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  • 1Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.


The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappaB (NF-kappaB) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.

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