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J Clin Gastroenterol. 2008 Jul;42 Suppl 2:S80-4. doi: 10.1097/MCG.0b013e318169c44e.

Probiotics and liver disease.

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  • 1Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06520-8000, USA.


Modulation of intestinal flora through the use of probiotics is an emerging therapeutic strategy in the management of chronic liver diseases. This article focuses on the pathophysiologic basis for using probiotics in liver disease and reviews the existing literature on the subject. The role of probiotics is examined in the following areas: a) prevention of infection, b) the hyperdynamic circulatory state of cirrhosis, c) hepatic encephalopathy, d) liver function, and e) nonalcoholic fatty liver disease.

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