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    Am J Clin Nutr. 2008 Jun;87(6):2003S-9S.

    n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects.

    Jung UJ, Torrejon C, Tighe AP, Deckelbaum RJ.

    Source

    Department of Pediatrics, Institute of Human Nutrition, College of Physicians and Surgeons of Columbia University, and Scientiae, LLC, New York, NY 10032, USA.

    Abstract

    Dietary n-3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid, are important nutrients through the life cycle. Evidence from observational, clinical, animal, and in vitro studies indicates a beneficial role of n-3 fatty acids in the prevention and management of cardiovascular disease. Although the precise mechanisms are still unclear, clinical and preclinical studies indicate that the cardioprotective effects of n-3 fatty acids may be attributed to a number of distinct biological effects on lipid and lipoprotein metabolism, blood pressure, platelet function, arterial cholesterol delivery, vascular function, and inflammatory responses.

    PMID:
    18541602
    [PubMed - indexed for MEDLINE]

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