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Adv Drug Deliv Rev. 2008 Sep;60(12):1421-34. doi: 10.1016/j.addr.2008.04.012. Epub 2008 Apr 24.

Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance.

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  • 1Department Chemical Engineering, Massachusetts Institute of Technology, USA.

Abstract

Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous distribution of these agents in tumors when administered systemically. Large regions of untargeted cells can therefore escape therapy and potentially select for more resistant cells. We present here a summary of theoretical and experimental approaches to analyze and improve antibody penetration in tumor tissue.

PMID:
18541331
[PubMed - indexed for MEDLINE]
PMCID:
PMC2820307
Free PMC Article

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