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Cell Host Microbe. 2008 Jun 12;3(6):399-407. doi: 10.1016/j.chom.2008.05.006.

Mycobacterium tuberculosis and the macrophage: maintaining a balance.

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  • 1Biozentrum, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.


Mycobacterium tuberculosis is a highly efficient pathogen, killing millions of infected people annually. The capacity of M. tuberculosis to survive and cause disease is strongly correlated to their ability to escape immune defense mechanisms. In particular, M. tuberculosis has the remarkable capacity to survive within the hostile environment of the macrophage. Understanding M. tuberculosis virulence strategies will not only define novel targets for drug development but will also help to uncover previously unknown signaling pathways related to the host's response to M. tuberculosis infection.

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