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Nihon Rinsho. 2008 Jun;66(6):1149-54.

[Myasthenia gravis induced by autoantibodies against MuSK].

[Article in Japanese]

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  • 1Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of Gerontology.


Myasthenia gravis (MG) is caused by the failure of neuromuscular transmission mediated by autoantibodies. That is, the binding of autoantibodies to postsynaptic membranes in neuromuscular junctions (NMJ) results in weakening of the ocular, bulbar and limb muscles and produces the characteristic syndrome of MG. About 80 to 85% of patients witth MG have autoantibodies against acetylcholine receptors (AChR). Antibodies against muscle-specific kinase (MuSK) have been found in 30% of MG patients without AChR antibodies. Here we describe recent progress toward understanding the pathogenic role of MuSK antibodies in the decline of muscle strength that typifies MG.

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