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    J Child Neurol. 2008 Jun;23(6):699-702.

    Increased intracranial pressure in a case of pediatric multiple sclerosis.

    Williams BJ, Skinner HJ, Maria BL.

    Source

    Department of Neurosciences, Charles P. Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA.

    Abstract

    A 15-year-old girl presented to our emergency department with dizziness, anorexia, nausea, and malaise. Clinical examination and magnetic resonance imaging studies showed characteristic features of multiple sclerosis. Surprisingly, a diagnostic lumbar puncture showed significant intracranial hypertension in addition to numerous oligoclonal bands, elevated immunoglobulin G index and immunoglobulin G/albumin ratio in the cerebrospinal fluid. It is proposed that a large burden of active demyelinating disease may cause increased intracranial pressure, thus providing an additional sound rationale for prompt therapeutic administration of intravenous high-dose steroids.

    PMID:
    18539995
    [PubMed - indexed for MEDLINE]

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