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Protein Pept Lett. 2008;15(5):505-9.

Computational analyses of TBC protein family in eukaryotes.

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  • 1Hefei National Laboratory for Physical Science, Hefei, Anhui 230027, China.


Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.

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