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Gynecol Obstet Invest. 2008;66(3):152-6. doi: 10.1159/000135712. Epub 2008 Jun 6.

A search for Helicobacter pyloriin localized vulvodynia.

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  • 1Women's Health Center, Lin Clinic, Haifa, Israel.

Abstract

BACKGROUND:

We noted that several patients presenting with both localized vulvodynia (vulvar vestibulitis) and peptic symptoms reported a resolution of dyspareunia after receiving a full treatment course for Helicobacter pylori.

METHODS:

Women with localized vulvodynia were interviewed regarding symptoms of peptic disease. Those with peptic symptoms underwent a blood test for the presence of antibodies to H. pylori and were referred to a gastroenterology consultation. In all women, vestibular biopsies were obtained and stained for H. pylori. Healthy vestibular tissues as well as archival negative and positive gastric tissues served as controls.

RESULTS:

Of the blood antibody tests, 12 (80%) were positive. None of the patients had evidence of H. pylori in the vestibule. Eleven women received triple therapy for eradication of H. pylori. Eight (73%) reported complete relief of dyspareunia and of gastric symptoms.

CONCLUSION:

Our study found no immunohistochemical evidence of H. pylori infection in the vestibule but suggested a possible role for anti-H. pylori treatment in localized vulvodynia.

Copyright 2008 S. Karger AG, Basel.

[PubMed - indexed for MEDLINE]
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