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1: Bioinformatics. 2008 Aug 1;24(15):1737-9. Epub 2008 Jun 5.Click here to read Click here to read Links

LOT: a tool for linkage analysis of ordinal traits for pedigree data.

Zhang M, Feng R, Chen X, Hu B, Zhang H.

Yale University School of Medicine, New Haven, CT 06520-8034, USA.

SUMMARY: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. AVAILABILITY: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/

PMID: 18535081 [PubMed - indexed for MEDLINE]

PMCID: PMC2566542