Mayo Clin Proc. 2008 Jun;83(6):701-6; quiz 706-7.

Human papillomavirus and vaccination.

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Department of Internal Medicine, UCLA School of Medicine, VA Greater Los Angeles Healthcare System, West Los Angeles, California. 11301 Wilshire Blvd (PACC), Los Angeles, CA 90073, USA.

Abstract

Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the United States. Modeling estimates suggest that more than 80% of sexually active women will have acquired genital HPV by age 50 years. Although most infections are transient and asymptomatic, persistent infection with high-risk types of HPV can lead to precancerous lesions and progress to cancer. In June 2006, the US Food and Drug Administration licensed the first vaccine to prevent cervical cancers and other diseases in women. This quadrivalent vaccine protects against HPV-6, HPV-11, HPV-16, and HPV-18, which are responsible for 70% of cervical cancers and 90% of genital warts. Several studies have been published examining the vaccine's efficacy, duration, immunogenicity, and safety. Questions and controversy remain regarding mandatory vaccination, need for booster doses, and cost-effectiveness.

PMID:: 18533087; [PubMed - indexed for MEDLINE]

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Review

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Papillomavirus Vaccines

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Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers - International Agency for Research on Cancer - Screening Group

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Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP). [MMWR Recomm Rep. 2007]
Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP).
Markowitz LE, Dunne EF, Saraiya M, Lawson HW, Chesson H, Unger ER, Centers for Disease Control and Prevention (CDC), Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007 Mar 23; 56(RR-2):1-24.
Review Epidemiology, clinical manifestations, and recent advances in vaccination against human papillomavirus. [Postgrad Med. 2010]
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Broomall EM, Reynolds SM, Jacobson RM. Postgrad Med. 2010 Mar; 122(2):121-9.
Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young women. [J Natl Cancer Inst. 2010]
Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young women.
Muñoz N, Kjaer SK, Sigurdsson K, Iversen OE, Hernandez-Avila M, Wheeler CM, Perez G, Brown DR, Koutsky LA, Tay EH, et al. J Natl Cancer Inst. 2010 Mar 3; 102(5):325-39. Epub 2010 Feb 5.
Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial. [BMJ. 2010]
Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial.
FUTURE I/II Study Group, Dillner J, Kjaer SK, Wheeler CM, Sigurdsson K, Iversen OE, Hernandez-Avila M, Perez G, Brown DR, Koutsky LA, et al. BMJ. 2010 Jul 20; 341:c3493. Epub 2010 Jul 20.
Review Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials. [CMAJ. 2007]
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Rambout L, Hopkins L, Hutton B, Fergusson D. CMAJ. 2007 Aug 28; 177(5):469-79. Epub 2007 Aug 1.

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Cited by 3 PubMed Central articles

Attitudes toward HPV Vaccination among Women Aged 27 to 45. [ISRN Obstet Gynecol. 2011]
Attitudes toward HPV Vaccination among Women Aged 27 to 45.
Weiss TW, Rosenthal SL, Zimet GD. ISRN Obstet Gynecol. 2011; 2011:670318. Epub 2011 Apr 7.
The cross-cultural variation of predictors of human papillomavirus vaccination intentions. [J Womens Health (Larchmt). 2011]
The cross-cultural variation of predictors of human papillomavirus vaccination intentions.
Lechuga J, Swain GR, Weinhardt LS. J Womens Health (Larchmt). 2011 Feb; 20(2):225-30.
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