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1: Cancer Inform. 2007 Dec 12;3:389-407.Click here to read Click here to read Links

Public Databases and Software for the Pathway Analysis of Cancer Genomes.

Tsui IF, Chari R, Buys TP, Lam WL.

Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

The study of pathway disruption is key to understanding cancer biology. Advances in high throughput technologies have led to the rapid accumulation of genomic data. The explosion in available data has generated opportunities for investigation of concerted changes that disrupt biological functions, this in turns created a need for computational tools for pathway analysis. In this review, we discuss approaches to the analysis of genomic data and describe the publicly available resources for studying biological pathways.

PMID: 18528531 [PubMed]

PMCID: PMC2410087