Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R704-13. doi: 10.1152/ajpregu.90337.2008. Epub 2008 Jun 4.

Teleost fish osmoregulation: what have we learned since August Krogh, Homer Smith, and Ancel Keys.

Author information

  • 1Department of Zoology, University of Florida, Gainesville, FL 32611, USA. devans@zoo.ufl.edu

Erratum in

  • Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1359.

Abstract

In the 1930s, August Krogh, Homer Smith, and Ancel Keys knew that teleost fishes were hyperosmotic to fresh water and hyposmotic to seawater, and, therefore, they were potentially salt depleted and dehydrated, respectively. Their seminal studies demonstrated that freshwater teleosts extract NaCl from the environment, while marine teleosts ingest seawater, absorb intestinal water by absorbing NaCl, and excrete the excess salt via gill transport mechanisms. During the past 70 years, their research descendents have used chemical, radioisotopic, pharmacological, cellular, and molecular techniques to further characterize the gill transport mechanisms and begin to study the signaling molecules that modulate these processes. The cellular site for these transport pathways was first described by Keys and is now known as the mitochondrion-rich cell (MRC). The model for NaCl secretion by the marine MRC is well supported, but the model for NaCl uptake by freshwater MRC is more unsettled. Importantly, these ionic uptake mechanisms also appear to be expressed in the marine gill MRC, for acid-base regulation. A large suite of potential endocrine control mechanisms have been identified, and recent evidence suggests that paracrines such as endothelin, nitric oxide, and prostaglandins might also control MRC function.

PMID:
18525009
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk