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J Endocrinol. 2008 Sep;198(3):439-50. doi: 10.1677/JOE-08-0161. Epub 2008 Jun 4.

Hedgehog signalling in endocrine development and disease.

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  • 1Barts and the London School of Medicine, Centre for Endocrinology, London EC1M 6BQ, UK.


The hedgehog (Hh) pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue and cellular properties such as patterning fields of cells or regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review, we provide an update on recent findings in the field of vertebrate Hh signalling and also describe contributions of Hh signalling to the development, maintenance and pathology of endocrine tissues.

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