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Curr Opin Pharmacol. 2008 Oct;8(5):557-63. doi: 10.1016/j.coph.2008.04.008. Epub 2008 Jun 3.

Renaissance in antibacterial discovery from actinomycetes.

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  • 1Drug Discovery and Evaluation, Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, MA 02421, USA. rbaltz@cubist.com

Abstract

The soil actinomycetes have been important sources of antibiotics, but were nearly abandoned in recent years in favor of high-throughput target-based screening of chemical libraries. The latter approach has not been productive, so it is time to reinvigorate the discovery of new antibiotics from a proven source. Recent progress has been made on antibiotic discovery from actinomycetes by using high-throughput fermentation, isolation of marine actinomycetes, mining genomes for cryptic pathways, and combinatorial biosynthesis to generate new secondary metabolites related to existing pharmacophores.

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