Rev Med Interne. 2008 Sep;29(9):696-700. Epub 2008 Jun 3.

[Interferon-alpha: a key cytokine in systemic lupus erythematosus pathogenesis].

[Article in French]

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Service de médecine interne, centre de référence national pour les lupus et le syndrome des antiphospholipides, CHU Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75651 Paris cedex 13, France. alexis.mathian@free.fr

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a chronic inflammation affecting multiple tissues and the production of antibodies directed against nuclear antigens. Leading observations in patients suggested years ago that interferon-alpha (IFNalpha) was involved in SLE pathogenesis. These observations have now been confirmed in SLE-prone mice. New promising therapeutic strategies, aiming at neutralizing IFNalpha or its effects, are currently under development.

PMID:: 18524426; [PubMed - indexed for MEDLINE]

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Interferon-alpha

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