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1: J Med Case Reports. 2008 Jun 3;2:191.Click here to read Click here to read Links

Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report.

Gundling F, Wittenburg H, Tannapfel A, Mossner J.

Second Department of Medicine, Bogenhausen Hospital, Academic Teaching Hospital, Technical University of Munich, Munich, Germany. Felix.Gundling@GMX.de.

ABSTRACT: INTRODUCTION: Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei. CASE PRESENTATION: We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset. CONCLUSION: The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of the central nervous system in all patients with Whipple's disease. If relapse of the central nervous system occurs treatment with meropenem might be a useful alternative.

PMID: 18522718 [PubMed - in process]

PMCID: PMC2443157

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  • Trimethoprim (Proloprim® )

    Trimethoprim eliminates bacteria that cause urinary tract infections. It is used in combination with other drugs to treat certain types of pneumonia. It also is used to treat 'travelers' diarrhea.' Antibiotics will not w...

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