Mamm Genome. 2008 Jun;19(6):379-81. Epub 2008 Jun 3.

The Collaborative Cross, developing a resource for mammalian systems genetics: a status report of the Wellcome Trust cohort.

Source

Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel. fuadi@post.tau.ac.il

Abstract

We report on the progress of a project funded by the Wellcome Trust to produce over 100 recombinant inbred mouse lines as part of the Collaborative Cross (CC) genetic reference panel. These new strains of mice are being derived from a set of eight genetically diverse founders. The genomes of the finished strains will be mosaics of the founder strains' genomes with a high density of independent recombination breakpoints. The CC mice will be available for distribution free of any intellectual property constraints to serve as a community resource for systems genetics studies.

PMID:: 18521666; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Grant Support

Wellcome Trust/United Kingdom

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Related citations

The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. [Mamm Genome. 2008]
The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics.
Chesler EJ, Miller DR, Branstetter LR, Galloway LD, Jackson BL, Philip VM, Voy BH, Culiat CT, Threadgill DW, Williams RW, et al. Mamm Genome. 2008 Jun; 19(6):382-9. Epub 2008 Aug 21.
The genomes of recombinant inbred lines. [Genetics. 2005]
The genomes of recombinant inbred lines.
Broman KW. Genetics. 2005 Feb; 169(2):1133-46. Epub 2004 Nov 15.
Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection. [Genome Res. 2011]
Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection.
Durrant C, Tayem H, Yalcin B, Cleak J, Goodstadt L, de Villena FP, Mott R, Iraqi FA. Genome Res. 2011 Aug; 21(8):1239-48. Epub 2011 Apr 14.
Review The collaborative cross: a recombinant inbred mouse population for the systems genetic era. [ILAR J. 2011]
Review The collaborative cross: a recombinant inbred mouse population for the systems genetic era.
Threadgill DW, Miller DR, Churchill GA, de Villena FP. ILAR J. 2011 Feb 8; 52(1):24-31.
Review Genes as gerontological variables: uniform genotypes. [Neurobiol Aging. 1999]
Review Genes as gerontological variables: uniform genotypes.
McClearn GE, Hofer SM. Neurobiol Aging. 1999 Mar-Apr; 20(2):95-104.

See reviews... See all...

Cited by 12 PubMed Central articles

H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. [MBio. 2011]
H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load.
Boon AC, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G, Webby RJ. MBio. 2011; 2(5). Epub 2011 Sep 6.
Genetic analysis in the Collaborative Cross breeding population. [Genome Res. 2011]
Genetic analysis in the Collaborative Cross breeding population.
Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, et al. Genome Res. 2011 Aug; 21(8):1223-38. Epub 2011 Jul 6.
Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection. [Genome Res. 2011]
Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection.
Durrant C, Tayem H, Yalcin B, Cleak J, Goodstadt L, de Villena FP, Mott R, Iraqi FA. Genome Res. 2011 Aug; 21(8):1239-48. Epub 2011 Apr 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The Collaborative Cross, developing a resource for mammalian systems genetics: a...
The Collaborative Cross, developing a resource for mammalian systems genetics: a status report of the Wellcome Trust cohort.
Mamm Genome. 2008 Jun ;19(6):379-81. Epub 2008 Jun 3 .

PubMed
Asymptomatic Leishmania infantum infection in an area of northwestern Italy (Pie...
Asymptomatic Leishmania infantum infection in an area of northwestern Italy (Piedmont region) where such infections are traditionally nonendemic.
J Clin Microbiol. 2010 Jan ;48(1):131-6. Epub 2009 Nov 18 .

PubMed
The role of complementary and alternative medicine (CAM) in Germany - a focus gr...
The role of complementary and alternative medicine (CAM) in Germany - a focus group study of GPs.
BMC Health Serv Res. 2008 Jun 12 ;8:127.

PubMed
The life span-prolonging effect of sirtuin-1 is mediated by autophagy.
The life span-prolonging effect of sirtuin-1 is mediated by autophagy.
Autophagy. 2010 Jan ;6(1):186-8. Epub 2010 Jan 2 .

PubMed
Availability of acupuncture in the hospitals of a major academic medical center:...
Availability of acupuncture in the hospitals of a major academic medical center: a pilot study.
Complement Ther Med. 2003 Sep ;11(3):177-83.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: