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Nat Cell Biol. 2008 Jun;10(6):637-9. doi: 10.1038/ncb0608-637.

p53: The Janus of autophagy?

Abstract

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

PMID:
18521069
[PubMed - indexed for MEDLINE]
PMCID:
PMC2739720
Free PMC Article

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