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Neurodegener Dis. 2008;5(5):296-303. doi: 10.1159/000135614. Epub 2008 Jun 3.

Towards noninvasive molecular fluorescence imaging of the human brain.

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  • 1Clinic of Neurology, Charité - Universitatsmedizin Berlin, Berlin, Germany. jens.steinbrink@charite.de

Abstract

Fluorescence molecular brain imaging is a new modality allowing the detection of specific contrast agents down to very low concentration ranges (picomolar) in disease models. Here we demonstrate a first noninvasive application of fluorescence imaging in the human brain, where concentrations down to about 100 nM of a nonspecific dye were detected. We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which - together with its bedside applicability - makes it a promising technique for use in patients.

(c) 2008 S. Karger AG, Basel

PMID:
18520164
[PubMed - indexed for MEDLINE]
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