Neurodegener Dis. 2008;5(5):296-303. doi: 10.1159/000135614. Epub 2008 Jun 3.

Towards noninvasive molecular fluorescence imaging of the human brain.

Steinbrink J, Liebert A, Wabnitz H, Macdonald R, Obrig H, Wunder A, Bourayou R, Betz T, Klohs J, Lindauer U, Dirnagl U, Villringer A.

Source

Clinic of Neurology, Charité - Universitatsmedizin Berlin, Berlin, Germany. jens.steinbrink@charite.de

Abstract

Fluorescence molecular brain imaging is a new modality allowing the detection of specific contrast agents down to very low concentration ranges (picomolar) in disease models. Here we demonstrate a first noninvasive application of fluorescence imaging in the human brain, where concentrations down to about 100 nM of a nonspecific dye were detected. We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which - together with its bedside applicability - makes it a promising technique for use in patients.

PMID:: 18520164; [PubMed - indexed for MEDLINE]

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Towards noninvasive molecular fluorescence imaging of the human brain.
Towards noninvasive molecular fluorescence imaging of the human brain.
Neurodegener Dis. 2008 ;5(5):296-303. doi: 10.1159/000135614. Epub 2008 Jun 3 .

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