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Genes Dev. 2008 Jun 1;22(11):1445-50. doi: 10.1101/gad.1663208.

Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.

Author information

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA. didier-stainier@biochem.ucsf.edu

Abstract

The mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By analyzing the effects of Ptf1a partial loss of function, we uncovered novel roles for this transcription factor in determining pancreatic fates. In a newly identified hypomorphic ptf1a mutant, pancreatic cells that would normally express ptf1a and become exocrine cells, express the endocrine marker Isl1, indicating a cell fate switch. Surprisingly, a milder reduction of Ptf1a leads to an even greater increase of ectopic endocrine cells, suggesting that Ptf1a also plays a role in promoting endocrine development. We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate.

PMID:
18519637
[PubMed - indexed for MEDLINE]
PMCID:
PMC2418581
Free PMC Article

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