Neuropharmacology. 1991 Feb;30(2):169-76.

Responsiveness of genetically epilepsy-prone rats to aminophylline-induced seizures and interactions with quinolones.

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Institute of Pharmacology, School of Medicine, University of Messina, Italy.

Abstract

The authors sought to determine whether different responsiveness to seizures induced by aminophylline existed between the genetically epilepsy-prone and normal rats. It was found that the seizure latency was consistently shorter in the genetically epilepsy-prone rats than in normal ones. A different pattern of response was observed in the progression to tonic seizures. In addition, seizures appeared to be more marked in genetically epilepsy-prone than in normal rats. A pretreatment with some quinolones (nalidixic acid, pipemidic acid, ciprofloxacin, norfloxacin, ofloxacin and enoxacin) significantly increased the convulsant properties of aminophylline. These studies demonstrated that the order of proconvulsant activity was ciprofloxacin greater than enoxacin greater than ofloxacin greater than norfloxacin greater than nalidixic acid greater than pipemidic acid. In addition, the present results showed that quinolones, having a fluorine atom showed the most marked proconvulsant activity.

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Repeated treatment with quinolones potentiates the seizures induced by aminophylline in genetically epilepsy-prone rats. [Gen Pharmacol. 1992]
Repeated treatment with quinolones potentiates the seizures induced by aminophylline in genetically epilepsy-prone rats.
De Sarro A, Trimarchi GR, Ammendola D, De Sarro G. Gen Pharmacol. 1992 Sep; 23(5):853-9.
Only some anticonvulsants protect against seizures induced by aminophylline in quinolone-treated genetically epilepsy prone rats. [Gen Pharmacol. 1993]
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De Sarro A, Ammendola D, Juliano M, Gareri P, De Sarro G. Gen Pharmacol. 1993 Nov; 24(6):1393-401.
[Interactions between quinolones and aminophylline in rats genetically predisposed to epilepsy]. [G Ital Chemioter. 1991]
[Interactions between quinolones and aminophylline in rats genetically predisposed to epilepsy].
De Sarro A, Trimarchi GR, De Sarro GB. G Ital Chemioter. 1991 Jan-Dec; 38(1-3):111-2.
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Periaqueductal gray neurons exhibit increased responsiveness associated with audiogenic seizures in the genetically epilepsy-prone rat.
N'Gouemo P, Faingold CL. Neuroscience. 1998 May; 84(2):619-25.

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Responsiveness of genetically epilepsy-prone rats to aminophylline-induced seizures and interactions with quinolones.

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