Abstract
In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5H-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6- (2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Benzopyrans / chemical synthesis
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Benzopyrans / pharmacology*
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Benzopyrans / toxicity
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Carrageenan
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Diclofenac / pharmacology
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Disease Models, Animal
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Female
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Hot Temperature
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Inflammation / chemically induced
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Inflammation / prevention & control*
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Lethal Dose 50
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Male
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Mice
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Molecular Structure
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Nitriles / chemical synthesis
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Nitriles / pharmacology*
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Nitriles / toxicity
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Pain / etiology
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Pain / physiopathology
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Pain / prevention & control*
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Pain Measurement
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Pain Threshold / drug effects
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Pyridines / chemical synthesis
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Pyridines / pharmacology*
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Pyridines / toxicity
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Rats
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Spectrum Analysis / methods
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Benzopyrans
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Nitriles
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Pyridines
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Diclofenac
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Carrageenan