Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2008 Jul;24(7):319-23. doi: 10.1016/j.tig.2008.04.006.

Comparison of transcription regulatory interactions inferred from high-throughput methods: what do they reveal?

Author information

  • 1National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894, USA. sbalaji@ncbi.nlm.nih.gov

Abstract

We compared the transcription regulatory interactions inferred from three high-throughput methods. Because these methods use different principles, they have few interactions in common, suggesting they capture distinct facets of the transcription regulatory program. We show that these methods uncover disparate biological phenomena: long-range interactions between telomeres and transcription factors, downstream effects of interference with ribosome biogenesis and a protein-aggregation response. Through a detailed analysis of the latter, we predict components of the system responding to protein-aggregation stress.

PMID:
18514968
[PubMed - indexed for MEDLINE]
PMCID:
PMC2768723
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk