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Behav Neurosci. 2008 Jun;122(3):498-504. doi: 10.1037/0735-7044.122.3.498.

Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice.

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  • 1Division of Structural Cell Biology, Nara Institute of Science and Technology, Nara, Japan.

Abstract

Neuropsin (kallikrein-related peptidase 8) is concentrated in the hippocampus, amygdala, olfactory bulb, and prefrontal cortex. Earlier studies showed that protease deficiency causes a significant impairment of early-phase long-term potentiation in the Schaffer collateral pathway and hippocampus-dependent memory in the Y maze and Morris water maze (Z. Chen et al., 1995; A. Hirata et al., 2001; H. Tamura et al., 2006). In addition to neuropsin's participation in the hippocampal memory, amygdalar and cortical localization of the gene suggests extrahippocampal behavioral function, and the authors therefore examined neuropsin-deficient mice, including tests of sensory motor reflex, open field, light-dark transition, Rota-Rod, elevated plus-maze, hot plate, startle response-prepulse inhibition, Porsolt forced swim, Barnes maze, eight-arm radial maze, and contextual and cued fear conditioning tests. Here, the authors found increased anxiety in neuropsin-deficient mice, suggesting the involvement of this protease in emotional responses.

(Copyright) 2008 APA, all rights reserved.

PMID:
18513120
[PubMed - indexed for MEDLINE]
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