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Ned Tijdschr Geneeskd. 2008 Apr 12;152(15):876-9.

[New drugs; exenatide and sitagliptin].

[Article in Dutch]

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  • 1Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden.


Incretin hormones, secreted upon food intake, play an important role in the regulation of blood glucose levels. In type 2 diabetes mellitus, the incretin response is decreased. Substitution of incretin is a novel pharmacological target which restores postprandial glucose homeostasis. Exenatide is a mimetic of the incretin glucagon-like peptide-I (GLP-I). Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase 4 (DPP-4), which breaks down GLP-I. Both drugs increase the GLP-I concentration, thereby improving insulin secretion from pancreatic p cells, restoring glycaemic control, preventing beta cell destruction, delaying gastric emptying, and reducing food intake.

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