Cell. 2008 May 30;133(5):775-87.

Regulatory T cells and immune tolerance.

Sakaguchi S, Yamaguchi T, Nomura T, Ono M.

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Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. shimon@frontier.kyoto-u.ac.jp

Abstract

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.

PMID:: 18510923; [PubMed - indexed for MEDLINE]

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