Send to

Choose Destination
See comment in PubMed Commons below
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7506-10. doi: 10.1073/pnas.0711127105. Epub 2008 May 27.

Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants.

Author information

  • 1Department of Biology, University of Iowa, Iowa City, IA 52242, USA.


Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk