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Bioinformatics. 2008 Jul 15;24(14):1625-31. doi: 10.1093/bioinformatics/btn249. Epub 2008 May 28.

InteroPORC: automated inference of highly conserved protein interaction networks.

Author information

  • 1CEA, IBITECS, Gif sur Yvette, F-91191, France. michaut.bioinfo@gmail.com

Abstract

MOTIVATION:

Protein-protein interaction networks provide insights into the relationships between the proteins of an organism thereby contributing to a better understanding of cellular processes. Nevertheless, large-scale interaction networks are available for only a few model organisms. Thus, interologs are useful for a systematic transfer of protein interaction networks between organisms. However, no standard tool is available so far for that purpose.

RESULTS:

In this study, we present an automated prediction tool developed for all sequenced genomes available in Integr8. We also have developed a second method to predict protein-protein interactions in the widely used cyanobacterium Synechocystis. Using these methods, we have constructed a new network of 8783 inferred interactions for Synechocystis.

AVAILABILITY:

InteroPORC is open-source, downloadable and usable through a web interface at http://biodev.extra.cea.fr/interoporc/.

PMID:
18508856
[PubMed - indexed for MEDLINE]
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