Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Front Biosci. 2008 May 1;13:6991-8.

Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis.

Author information

  • 1Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. mzeisber@bidmc.harvard.edu

Abstract

Our current understanding of epithelial-mesenchymal transition (EMT) in the setting of tissue fibrosis is largely based on pioneering studies in the kidney. Evidence is emerging that EMT is a key component of chronic kidney disease, contributing to both destruction of the tubular epithelial compartment and accumulation of interstitial fibroblasts. While knowledge regarding EMT was previously based on experimental rodent studies, in recent years the evolving evidence demonstrates a role for EMT in human kidney diseases with chronic fibrosis.

PMID:
18508710
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers in Bioscience
    Loading ...
    Write to the Help Desk