Display Settings:

Format

Send to:

Choose Destination
Front Biosci. 2008 May 1;13:4862-72.

The role of chemokines during herpes simplex virus-1 infection.

Author information

  • 1Department of Microbiology, Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Abstract

Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens. Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 infection can cause blinding corneal disease, and individuals with defects in innate or adaptive immunity are susceptible to herpes simplex encephalitis. Chemokines regulate leukocyte trafficking to inflamed tissues and play a crucial role in orchestrating the immune response to HSV-1 infection. In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication.

PMID:
18508551
[PubMed - indexed for MEDLINE]
PMCID:
PMC2430744
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers in Bioscience Icon for PubMed Central
    Loading ...
    Write to the Help Desk