Curr Opin Cell Biol. 2008 Jun;20(3):341-8. Epub 2008 May 26.

Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.

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Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. ASH@Stowers-Institute.org

Abstract

Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.

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PMCID: PMC2504688

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