Horm Res. 2008;69(6):327-33. Epub 2008 Mar 17.

Advances in the management of paediatric Cushing's disease.

Savage MO, Chan LF, Afshar F, Plowman PN, Grossman AB, Storr HL.

Source

Department of Endocrinology, Barts and the London School of Medicine and Dentistry, London, UK. m.o.savage@qmul.ac.uk

Abstract

Cushing's disease (CD) is rare in the paediatric age range, but may present a difficult therapeutic challenge. Most paediatric endocrinologists have limited experience managing children or adolescents with CD and thus benefit from close consultation with adult colleagues. Prior to definitive treatment, a diagnostic protocol for investigation is required which broadly follows the model for adult patients. Treatment strategies for CD are described and critically appraised. The management of paediatric CD patients after cure also presents challenges for optimizing growth, bone health, reproduction and body composition from childhood into and during adult life.

PMID:: 18504391; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Adrenocorticotropic Hormone

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Corticotropin - HSDB

Supplemental Content

Icon for S. Karger AG, Basel, Switzerland

Save items

Related citations in PubMed

Review Diagnosis and treatment of Cushing's disease in children. [Endocr Dev. 2010]
Review Diagnosis and treatment of Cushing's disease in children.
Savage MO, Dias RP, Chan LF, Afshar F, Plowman NP, Matson M, Grossman AB, Storr HL. Endocr Dev. 2010; 17:134-45. Epub 2009 Nov 24.
Review Diagnosis and treatment of pediatric Cushing's disease. [Pituitary. 2007]
Review Diagnosis and treatment of pediatric Cushing's disease.
Savage MO, Storr HL, Chan LF, Grossman AB. Pituitary. 2007; 10(4):365-71.
Review Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances. [Trends Endocrinol Metab. 2007]
Review Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances.
Storr HL, Chan LF, Grossman AB, Savage MO. Trends Endocrinol Metab. 2007 May-Jun; 18(4):167-74. Epub 2007 Apr 6.
Review Work-up and management of paediatric Cushing's syndrome. [Curr Opin Endocrinol Diabetes ...]
Review Work-up and management of paediatric Cushing's syndrome.
Savage MO, Chan LF, Grossman AB, Storr HL. Curr Opin Endocrinol Diabetes Obes. 2008 Aug; 15(4):346-51.
Factors influencing cure by transsphenoidal selective adenomectomy in paediatric Cushing's disease. [Eur J Endocrinol. 2005]
Factors influencing cure by transsphenoidal selective adenomectomy in paediatric Cushing's disease.
Storr HL, Afshar F, Matson M, Sabin I, Davies KM, Evanson J, Plowman PN, Besser GM, Monson JP, Grossman AB, et al. Eur J Endocrinol. 2005 Jun; 152(6):825-33.

See reviews... See all...

Cited by 1 PubMed Central article

Review Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence. [Neuroimmunomodulation. 2009]
Review Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence.
Chrousos GP, Kino T, Charmandari E. Neuroimmunomodulation. 2009; 16(5):272-83. Epub 2009 Jun 29.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Advances in the management of paediatric Cushing's disease.
Advances in the management of paediatric Cushing's disease.
Horm Res. 2008 ;69(6):327-33. Epub 2008 Mar 17 .

PubMed
[Gonadotrophin dose and ovarian response: relations to the clinical outcome of i...
[Gonadotrophin dose and ovarian response: relations to the clinical outcome of in vitro fertilization and embryo transfer].
Nan Fang Yi Ke Da Xue Xue Bao. 2008 May ;28(5):712-4.

PubMed
Ethylene-induced opposite redistributions of calcium and auxin are essential com...
Ethylene-induced opposite redistributions of calcium and auxin are essential components in the development of tomato petiolar epinastic curvature.
Plant Physiol Biochem. 2008 Jul ;46(7):685-93. Epub 2008 Apr 18 .

PubMed
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cog...
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA.
Psychiatry Res. 2008 Jul 15 ;163(2):171-82. Epub 2008 May 27 .

PubMed
Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER st...
Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study.
Exp Gerontol. 2008 Aug ;43(8):801-5. Epub 2008 Apr 22 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: