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    FEBS Lett. 2008 Jun 25;582(15):2338-42. Epub 2008 May 27.

    Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes.

    He Y, Pan Q, Li J, Chen H, Zhou Q, Hong K, Brugada R, Perez GJ, Brugada P, Chen YH.

    Department of Cardiology, Tongji Hospital, Tongji University, Shanghai, China.

    Inward rectifier potassium Kir2.x channels mediate cardiac inward rectifier potassium currents (I(K1)). As a subunit of Kir2.x, the physiological role of Kir2.3 in native cardiomyocytes has not been reported. This study shows that Kir2.3 knock-down remarkably down-regulates Kir2.3 expression (Kir2.3 protein was reduced to 19.91+/-3.24% on the 2nd or 3rd day) and I(K1) current densities (at -120 mV, control vs. knock-down: -5.03+/-0.24 pA/pF, n=5 vs. -1.16+/-0.19 pA/pF, n=7, P<0.001) in neonatal rat cardiomyocytes. The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes.

    PMID: 18503768 [PubMed - indexed for MEDLINE]

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