Biochem Biophys Res Commun. 1991 Apr 15;176(1):213-8.

A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.

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Department of Medicine, University of Washington, Seattle 98195.

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Biochem Biophys Res Commun 1991 Jun 14;177(2):895.

Abstract

Insulin-like growth factor binding proteins (IGFBPs) modulate the cellular action of the insulin-like growth factors. Inhibition or enhancement of IGF effects by these cell-secreted binding proteins have been described. We have purified two IGFBPs (23 and 29 kDa) from media conditioned by U-2 human osteosarcoma cells using ligand-affinity chromatography and reversed phase HPLC. N-terminal amino acid analysis of the 23 kDa protein revealed a unique sequence with variable homology to IGFBPs 1-4. The 29 kDa IGFBP was found to be nearly identical to a recently reported IGFBP. Because the affinity purified U-2 IGFBPs enhanced IGF-I-stimulated osteoblast mitogenesis, we suggest that one or both of these binding proteins enhance IGF action in bone.

PMID:: 1850257; [PubMed - indexed for MEDLINE]

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