Mech Ageing Dev. 2009 Jan-Feb;130(1-2):54-7. Epub 2008 Apr 22.

Ageing within the hematopoietic stem cell compartment.

Source

Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.

Abstract

As we humans are far too aware, all mammals have a finite lifespan. Apart from basic longevity, age is also a major risk factor for most cancers and diseases. Since adult stem cells are responsible for maintaining tissue homeostasis throughout an organism's lifetime, an attractive theory is that ageing-related phenotypes might be, at least in part, due to an alteration in the number and/or function of tissue stem cells. Here, we have focused on hematopoietic stem cells as they are one of the best-characterized adult stem cell populations, and have been extensively studied for the consequences of ageing in vivo and in vitro.

PMID:: 18502471; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

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