Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Fungal Genet Biol. 2008 Aug;45 Suppl 1:S31-9. doi: 10.1016/j.fgb.2008.04.006. Epub 2008 May 23.

The homologous recombination system of Ustilago maydis.

Author information

  • 1Cornell University Weill Medical College, Department of Microbiology and Immunology, NY 10021, USA. wkhollo@med.cornell.edu

Abstract

Homologous recombination is a high fidelity, template-dependent process that is used in repair of damaged DNA, recovery of broken replication forks, and disjunction of homologous chromosomes in meiosis. Much of what is known about recombination genes and mechanisms comes from studies on baker's yeast. Ustilago maydis, a basidiomycete fungus, is distant evolutionarily from baker's yeast and so offers the possibility of gaining insight into recombination from an alternative perspective. Here we have surveyed the genome of U. maydis to determine the composition of its homologous recombination system. Compared to baker's yeast, there are fundamental differences in the function as well as in the repertoire of dedicated components. These include the use of a BRCA2 homolog and its modifier Dss1 rather than Rad52 as a mediator of Rad51, the presence of only a single Rad51 paralog, and the absence of Dmc1 and auxiliary meiotic proteins.

PMID:
18502156
[PubMed - indexed for MEDLINE]
PMCID:
PMC2583931
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk